goBHB® and BDNF: Fuel Your Brain Like It Deserves​

goBHB® and BDNF: Fuel Your Brain Like It Deserves

By: Marc Lobliner, IFBB Pro

Let’s talk about something most people overlook when it comes to energy, focus, and long-term performance: your brain. Not just how sharp it feels today, but how well it holds up over time. That’s where goBHB® comes in—and specifically, what it does to a molecule called BDNF.

This isn’t just another ingredient. This is real, clinical, bioavailable brain fuel—and it’s changing the game.

What the heck is BDNF—and why should you care?

BDNF stands for brain-derived neurotrophic factor. Think of it like Miracle-Gro for your brain. It helps grow new neurons, strengthens the ones you already have, and keeps your brain plastic—which means adaptable, sharp, and hard to break down.

Low BDNF levels? You’re looking at a higher risk of depression, anxiety, Alzheimer’s, poor memory, and honestly, just not feeling like yourself.

If you’re serious about your mental health, your focus, and long-term resilience, BDNF isn’t optional. It’s mandatory.

How goBHB® fires up BDNF naturally

Here’s where it gets real. goBHB® doesn’t just give you energy—it tells your body to be better. It gets into your bloodstream fast, crosses into the brain, and starts turning the right genes on. One of those genes? BDNF.

The magic happens through something called HDAC inhibition. That’s a fancy way of saying goBHB® unlocks your DNA to express the stuff that protects your brain—like antioxidant enzymes, mitochondrial repair pathways, and yes, BDNF.

It also increases PGC-1α, a coactivator that ramps up mitochondrial biogenesis. That’s more energy where it matters—inside your brain cells.

And we’re not just talking theory. This is backed by animal studies, human ketone research, and emerging data showing that when ketone levels go up, cognitive performance improves—and BDNF goes with it.

Why goBHB® is better than 1,3-butanediol—and it’s not even close

Look, a lot of companies out there are selling you 1,3-butanediol and calling it a ketone. It’s not. It’s an alcohol that your body has to convert into BHB—and that conversion takes ATP. That means it costs you energy to get any benefit.

Not only that, it can cause bloating, GI distress, and slow delivery. It’s not efficient, and it’s definitely not optimized for brain performance.

goBHB® is already in its active form. Your body doesn’t need to convert anything. It’s ready to use. That means faster results, cleaner performance, and real metabolic impact without the junk.

What this means for your brain and your performance

So what happens when your brain is running on clean fuel and BDNF is up?

You think faster. You focus longer. You adapt better to stress. You’re more resilient.

It’s like upgrading from a cheap gas station energy drink to rocket fuel—and your brain knows the difference.

This isn’t just for athletes. It’s for busy professionals, parents, students, anyone who wants to perform better and feel better—without the crash, the sugar, or the stimulants.

The proof is in performance

In 2024, both the men’s and women’s cross country teams at BYU won national championships while taking goBHB® daily. They used it for energy, for recovery, and for mental sharpness—and it delivered.

And it’s not just athletes. We’ve got professionals using this before meetings, students using it during finals, and everyday people using it to finally feel in control of their brain again.

Why goBHB® is leading the future of functional nutrition

Wellness is changing. People want real ingredients that do more. Not just hype. Not just caffeine.

They want metabolic health. Cognitive performance. Clean energy. And goBHB® checks all those boxes.

If you’re looking for the next evolution of performance fuel—something that supports your body and brain at the same time—goBHB® is it. You’re not just running on ketones. You’re running on momentum.

 

And that momentum? Starts with BDNF.

goBHB is direct Energy

The energy drink category has become absolutely loaded these past couple of years, thanks to established names expanding further, closely related brands expanding into the space, and newcomers trying their hand at the industry. The beverage we have in the spotlight here is certainly not one we saw coming, primarily due to the company behind it being so distant with REV7, a diverse, functional energy drink from the pillow manufacturer MyPillow.

goBHB Dosing: How Much You Need—And Why Even a Little Might Do A Lot

goBHB Dosing: How Much You Need—And Why Even a Little Might Do A Lot

By: Marc Lobliner, IFBB Pro

We’ve said it before and we’ll say it again: goBHB® is a game-changer. As one of the most efficient and research-backed ketone fuels available, it supports performance, cognition, energy, appetite control, and more. But one question comes up over and over again:

How much goBHB do I really need to feel the effects?

Traditionally, doses of 6 to 12 grams per serving have been used in supplements and clinical studies. But here’s where things get interesting: we’ve seen mounting anecdotal evidence that doses as low as 250 to 500 milligrams can deliver noticeable benefits for certain users and specific goals.

That doesn’t mean higher doses are ineffective—in fact, quite the opposite. Higher doses may amplify endurance, blood ketone levels, recovery, and anti-inflammatory effects. But it’s becoming clear that even small amounts of goBHB may offer meaningful support, especially for mental energy, focus, and appetite regulation.

Let’s break it down.

What is goBHB?

goBHB® is a patented, exogenously produced form of beta-hydroxybutyrate (BHB)—the primary ketone your body produces during fasting or carbohydrate restriction. At Ketone Labs, we offer a full-spectrum BHB that includes both D- and L-isomers, reflecting the diversity of how BHB is utilized in human metabolism.

BHB is not just a fuel—it’s also a signaling molecule that interacts with multiple systems in the body, including the brain, muscles, and immune pathways. Whether you’re on a ketogenic diet or not, supplementing with goBHB delivers rapid, clean-burning energy without the jitters, crashes, or digestive stress of stimulants.

Traditional Dosing: 6–12 Grams

This is the clinically studied range you’ll find in most high-performance endurance, cognitive, and weight-management products.

Why this range?

  • It’s the amount needed to raise blood ketone levels to ~0.5–1.0 mmol/L—levels associated with nutritional ketosis

  • Research in athletes shows improvements in time-to-exhaustion, mental focus, and reduced appetite

  • Clinical trials often standardize around this range to ensure consistent, measurable changes in biomarkers

For anyone looking to use goBHB for serious training, recovery, appetite control, or even metabolic health, these higher doses are well-validated.

But What About Lower Doses?

Here’s where things get fascinating.

Through anecdotal reports, field testing, and early-stage data, we’ve observed that many individuals experience benefits at doses as low as 250–500mg. This includes:

  • Improved mental clarity and reduced brain fog

  • A subtle but noticeable boost in energy and focus

  • Blunted appetite and cravings between meals

  • Enhanced calm and resilience during stressful moments

These micro-effects seem to be especially noticeable when goBHB is taken in a dry format (like a chewable or powder), or on an empty stomach. Some users report feeling a difference within minutes—long before blood ketone levels would even spike.

The Potential Sublingual Effect

One theory gaining traction is that goBHB may partially absorb through the sublingual (under-the-tongue) route, especially when taken in dry form.

Why this matters:

  • BHB is a small, water-soluble molecule, much like glucose analogs and amino acids

  • Sublingual absorption bypasses digestion and the liver, potentially allowing faster entry into the bloodstream

  • Users taking 250–500mg dry, under the tongue or in chewable form, often report rapid onset effects

At Ketone Labs, we’re actively exploring this hypothesis in controlled environments. While more data is needed, the early signals are promising—and could change the way we think about delivery methods in ketone supplementation.

Why Less Might Work

Here’s the key takeaway: you don’t always need to chase a big number on your ketone meter to feel better, think clearer, or perform stronger.

Small amounts of goBHB may:

  • Support brain energy metabolism and mood regulation

  • Trigger cellular signaling pathways involved in inflammation control, mitochondrial efficiency, and gene expression

  • Act as a metabolic primer, giving your body just enough of a clean-burning fuel to elevate performance


Where the Research is Going

At Ketone Labs, we’re not just making bold claims—we’re backing them with science. Here’s what we’re currently exploring:

  • The minimal effective dose of goBHB for various benefits (focus, appetite, training)

  • How lower daily doses may support brain function, inflammation markers, and long-term metabolic health

  • Whether mixed-isomer forms (L+D) offer broader benefit profiles than isolated isomers

We’re committed to transparency, innovation, and giving consumers real, research-backed dosing guidance as the data emerges.


Final Thoughts

goBHB isn’t just a keto supplement—it’s a human performance tool. Whether you’re training hard, thinking deeply, or just trying to stay sharp, it’s one of the cleanest, most versatile fuels you can put in your body.

While 6 to 12 grams per day remains a gold standard for many goals, don’t overlook the power of a precision approach. With emerging evidence that even 250–500mg may provide benefits, we’re entering a new era of micro-targeted metabolic support.

At Ketone Labs, we’re proud to lead the way with full-spectrum goBHB and cutting-edge research that puts real results—and real science—in your hands.

Stay tuned. We’re just getting started.

References

  1. Veech, R.L. (2004). The therapeutic implications of ketone bodies. Prostaglandins Leukot Essent Fatty Acids, 70(3), 309–319.

  2. Cox, P.J., et al. (2016). Nutritional Ketosis Alters Fuel Preference and Endurance Performance in Athletes. Cell Metabolism, 24(2), 256–268.

  3. Stubbs, B.J., et al. (2017). Exogenous ketone supplements reduce appetite and hunger in overweight humans. Appetite, 117, 23–33.

  4. Shojaei, A.H. (1998). Buccal mucosa as a route for systemic drug delivery: a review. J Pharm Pharm Sci, 1(1), 15–30.

  5. Youm, Y.-H., et al. (2015). The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease. Nat Med, 21(3), 263–269.

  6. Shimazu, T., et al. (2013). Suppression of oxidative stress by β-hydroxybutyrate, an endogenous HDAC inhibitor. Science, 339(6116), 211–214.

Why Every Endurance Supplement Should Include goBHB

Why Every Endurance Supplement Should Include goBHB

By: Marc Lobliner, IFBB Pro

I don’t care if you’re a triathlete, marathoner, cyclist, or just a weekend warrior putting in the miles—if your endurance formula doesn’t include goBHB, it’s incomplete. Period. The science is there, the performance is real, and the benefits go far beyond energy.

We’re not just talking about “keto” here. We’re talking about one of the most efficient fuels your body can run on—beta-hydroxybutyrate (goBHB)—and why it should be in every single product marketed for endurance.

1. goBHB Is a Clean, Efficient Fuel Source

goBHB is a ketone body, a natural energy substrate your body produces during fasting, carbohydrate restriction, or extended exercise. But when you take it exogenously (as a supplement), your body gets all the energy benefits of ketosis—without the diet.

Let’s get technical for a second.

When you consume goBHB:

  • It skips glycolysis and goes straight into the mitochondria for ATP production.

  • It produces more ATP per unit of oxygen than glucose or fat [1].

  • That means you get more energy output with less oxygen demand, which is exactly what you need during endurance performance.

In high-output situations like marathons, ultra events, or long training sessions, your body starts to deplete glycogen. Instead of hitting the wall, goBHB provides an immediate alternate fuel source that spares glycogen and prolongs performance [2].

2. goBHB Delays Fatigue and Preserves Muscle

Ever bonk on a run or cramp up on mile 20? That’s your body crying out for fuel and balance. BHB helps solve that.

In a study published in Cell Metabolism, elite cyclists who supplemented with ketones experienced 28% greater endurance performance compared to those who didn’t [3]. That’s not a small edge—that’s a podium-level advantage.

And there’s more:

  • BHB has anti-catabolic properties, meaning it reduces muscle breakdown during prolonged training [4].

  • It blunts the rise in cortisol and other stress hormones that normally go through the roof in ultra-endurance efforts.

  • It also enhances recovery by reducing inflammation and oxidative stress post-exercise [5].

Translation: You can go longer, recover faster, and stay leaner.

3. Electrolyte Co-Delivery = Better Hydration + Cramp Prevention

goBHB doesn’t come alone. It’s typically bonded to essential electrolytes like sodium, calcium, and magnesium—making it a dual-action endurance tool.

Think about it:

  • You lose sodium, potassium, and magnesium through sweat.

  • You need to replenish those to avoid cramps, fatigue, and brain fog.

  • goBHB-based salts do exactly that, while also delivering clean fuel.

Most endurance supplements throw in electrolytes and call it a day. But with goBHB, you’re combining electrolyte support + metabolic enhancement in one.

This makes it an obvious choice for hot-weather races, long-distance events, or even fasted cardio.

4. Cognitive Focus and Mental Clarity Under Fatigue

You’re not just racing your body—you’re racing your mind.

When glucose runs low, brain fog and poor decision-making set in. BHB crosses the blood-brain barrier and acts as an alternative fuel for your brain, giving you heightened clarity and focus when others are crashing mentally [6].

In high-stakes endurance events, one bad decision can cost you the race. goBHB helps keep your brain firing when it counts most.

5. It Works WITH Carbs — Not Against Them

Let’s kill the myth: you don’t need to be on a keto diet to benefit from ketones.

goBHB can be taken with carbs. In fact, studies show stacking ketones with carbs improves endurance performance even further [7]. Carbs refill glycogen. Ketones preserve it and offer a parallel energy stream. It’s the best of both worlds.

So endurance supplements shouldn’t ditch carbs—they should add goBHB to enhance them.

The Bottom Line

If you’re formulating an endurance product and you’re leaving out goBHB, you’re doing it wrong. Athletes want more than just sugar, sodium, and caffeine. They want:

  • Clean energy

  • Muscle protection

  • Electrolyte balance

  • Mental focus

  • Faster recovery

And goBHB delivers on all of it.

It’s time to evolve endurance nutrition. And that starts with adding goBHB to every endurance stack out there.

Train longer. Recover faster. Perform better.

📚 References:

  1. Veech, R.L. (2004). “The therapeutic implications of ketone bodies.” Prostaglandins Leukot Essent Fatty Acids, 70(3), 309–319.

  2. Pinckaers, P.J., et al. (2017). “Exogenous ketone supplementation and endurance exercise performance.” Sports Medicine, 47(3), 513–523.

  3. Cox, P.J., et al. (2016). “Nutritional Ketosis Alters Fuel Preference and Endurance Performance in Athletes.” Cell Metabolism, 24(2), 256–268.

  4. D’Agostino, D.P., et al. (2013). “Ketone bodies and protection against muscle wasting.” Nutrition & Metabolism, 10:29.

  5. Stubbs, B.J., et al. (2017). “On the Metabolism of Exogenous Ketones in Humans.” Frontiers in Physiology, 8, 848.

  6. Newman, J.C., et al. (2014). “Ketone Bodies Improve Cognition and Protect the Brain.” Neurobiology of Aging, 35(6), 1316–1323.

  7. Evans, M., et al. (2018). “Exogenous ketone supplementation improves time trial performance in elite cyclists.” Nutrition, 57, 1–7.

Why Every Football Player Should Take goBHB—From Pee Wee to Pro​

Why Every Football Player Should Take goBHB—From Pee Wee to Pro

By: Marc Lobliner, IFBB Pro

Football is brutal. That’s the beauty of it—and the problem. High-impact collisions, repeated sprints, metabolic stress, and brain trauma are just another day on the field. That’s why I’m going to make this simple: every football player, regardless of age or level, should be taking goBHB (beta-hydroxybutyrate). Here’s why.

1. goBHB Protects the Brain From Concussions and Enhances Recovery

Football has a concussion problem. Repeated head trauma—even sub-concussive hits—cause long-term brain damage. But research shows ketones like BHB can help.

A 2017 study published in Frontiers in Molecular Neuroscience found that BHB reduces oxidative stress and neuronal death after traumatic brain injury (TBI), improving outcomes in rodent models [1]. BHB also inhibits NLRP3 inflammasome activation, a key driver of neuroinflammation in TBI and chronic traumatic encephalopathy (CTE) [2]. A study in Journal of Cerebral Blood Flow & Metabolism showed ketone bodies improve cerebral metabolism and cognitive outcomes post-injury [3].

That means BHB isn’t just a fuel—it’s brain protection.

2. BHB Provides a Superior Energy Source for Explosive Movement

Football is stop-and-go. It’s anaerobic. You need power, and you need it fast. While carbs are great, ketones offer another gear.

A 2016 study in Cell Metabolism showed ketone supplementation increased endurance and muscle efficiency by 28% in elite athletes [4]. BHB bypasses glycolysis and goes straight into the mitochondria for cleaner, faster ATP production, reducing lactic acid buildup [5]. It also spares glycogen, helping athletes maintain intensity deep into games or practice.

You get more energy with less fatigue, especially when paired with carbohydrates—no need to go full keto.

3. goBHB Accelerates Recovery by Reducing Inflammation

Soreness and systemic inflammation are real in football. You don’t have time to recover. That’s where BHB comes in.

BHB lowers IL-1β, IL-6, and TNF-α, the major inflammatory cytokines elevated after intense training or impact [6]. A 2021 paper in Cell Reports confirmed BHB’s epigenetic role in reducing inflammation by inhibiting histone deacetylases (HDACs) [7].

In simpler terms? Less soreness. Less tissue damage. Faster recovery.

4. goBHB Supports Muscle Preservation and Electrolyte Balance

BHB can also protect against muscle catabolism, especially in calorie-restricted or high-volume training periods.

A 2018 study in FASEB Journal found that BHB suppresses muscle breakdown by inhibiting proteolytic pathways [8]. It also naturally carries sodium, calcium, magnesium, and potassium, helping football players stay hydrated and avoid cramps, especially in heat [9].

It’s a built-in performance and hydration formula.

5. It’s Safe for Young Athletes—Backed by Clinical Trials

goBHB is GRAS-certified (Generally Recognized as Safe) and has been used in pediatric populations with epilepsy for decades in medical ketogenic diets.

A 2019 trial published in Pediatric Neurology showed BHB safely improved cognition and motor control in children on ketogenic therapies [10].

No stimulants. No crashes. Just clean, proven performance fuel—safe for middle schoolers and monsters in the NFL.

 

The Bottom Line

Football players don’t just need fuel. They need protection, recovery, and resilience. goBHB delivers all of that. You don’t have to eat bacon and butter all day—just add goBHB to your existing diet, especially pre- or post-training.

For best results, football players should take 10–12 grams of goBHB per day, ideally split into two doses:

  • On game or training days:

    • 5–6g 30 minutes before activity for clean energy and sharper focus

    • 5–6g immediately after for inflammation control and faster recovery

  • On non-training days:

    • 5–6g first thing in the morning to support brain health and daily energy

    • Optional second dose (5–6g mid-afternoon) to maintain ketone levels, aid recovery, and reduce brain fog

You can mix it with water, electrolytes, or a carb source depending on timing and goals. Adjust slightly for age and body size, but this protocol is effective and research-supported. You can also take it by drinking Rev7 or powering up with Let’s Go BHB.

The data is clear. The benefits are undeniable. And if you’re not using goBHB yet—you’re behind.

Train smarter. Recover faster. Play longer.

References

  1. Lee, D. C., et al. (2017). “Ketone Bodies and the Brain.” Front. Mol. Neurosci., 10:386.

  2. Youm, Y. H., et al. (2015). “The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease.” Nat Med 21, 263–269.

  3. Prins, M. L., & Matsumoto, J. H. (2014). “The benefits of ketone bodies in traumatic brain injury.” J Cereb Blood Flow Metab, 34(1), 69-76.

  4. Cox, P. J., et al. (2016). “Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes.” Cell Metabolism, 24(2), 256–268.

  5. Veech, R. L. (2004). “The therapeutic implications of ketone bodies.” Prostaglandins Leukot Essent Fatty Acids, 70(3), 309–319.

  6. Koutnik, A. P., et al. (2019). “Ketone Bodies Suppress Inflammation via Mitochondrial Respiration.” Med Hypotheses, 122, 111–116.

  7. Shimazu, T., et al. (2013). “Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor.” Science, 339(6116), 211–214.

  8. D’Agostino, D. P., et al. (2018). “Therapeutic Ketosis and the Ketogenic Diet in Muscle Preservation.” FASEB J, 32(S1).

  9. Poff, A. M., et al. (2020). “Ketone Supplementation and Athletic Performance.” Nutrition and Metabolism, 17(1): 75.

  10. Kverneland, M., et al. (2019). “Safety and Efficacy of Beta-Hydroxybutyrate Supplementation in Children.” Pediatr Neurol, 98, 39-45.

goBHB: The Future of Stimulant-Free Pre-Workouts for Evening Athletes

Evening workouts often pose a challenge: the need for energy and focus without the sleep disturbances caused by traditional stimulant-based pre-workouts. While many stimulant-free options exist, they frequently lack effective energy-boosting components. goBHB, a form of beta-hydroxybutyrate, offers a solution by providing direct cellular energy through ATP production, enhancing both performance and sleep quality.

PricePlow proposes two hypothetical goBHB-powered pre-workout formulations tailored for evening trainers. The first is a realistic, cost-effective blend featuring goBHB, L-citrulline, beta-alanine, creatine monohydrate, and cognitive enhancers like L-tyrosine and citicoline. The second is a full-power version that pushes the boundaries of stimulant-free performance. These concepts aim to inspire brands to develop effective, stimulant-free pre-workouts that support both energy and recovery for those who train later in the day.

Source: blog.priceplow.com/formulators-corner/gobhb-stim-free-preworkouts

ATP Overdrive: Methylene Blue, NAD⁺, or BHB – Which Powers You Best?​

ATP Overdrive: Methylene Blue, NAD⁺, or BHB – Which Powers You Best?

By: Marc Lobliner, IFBB Pro

You want energy. Not the “two cups of coffee and hope for the best” kind—real, cellular, deep-in-your-core energy. The kind that fuels your workouts, sharpens your brain, and keeps your metabolism firing like a jet engine.

And when we’re talking about energy at the cellular level, we’re really talking about ATP—adenosine triphosphate, your body’s raw currency of energy.

There’s a lot of buzz in the biohacking and performance world about three major players in the ATP game: Methylene Blue, NAD⁺, and BHB (beta-hydroxybutyrate). I’ve used all of them, studied the data, and I’m here to break it down so you know what’s hype and what’s high-performance fuel.

Methylene Blue: The Electron Shortcut

What it does:
Methylene Blue is an old-school compound with modern-day mitochondrial benefits. It acts like a bypass lane on the mitochondrial highway—accepting electrons from NADH and donating them directly to cytochrome c in the electron transport chain. Translation? It skips the parts of your mitochondria that are typically sluggish or broken down (Complex I and III).

Why it matters:

  • Boosts ATP in aging or damaged mitochondria

  • Reduces oxidative stress (less ROS = less cellular damage)

  • Neuroprotective, especially in conditions like Alzheimer’s

When to use it:
If you’re battling chronic fatigue, cognitive decline, or recovering from stress or illness, this is a smart hack. It doesn’t replace fuel—it fixes the engine.

NAD⁺: The Spark Plug of Metabolism

What it does:
NAD⁺ is a coenzyme, which basically means it’s the unsung hero behind hundreds of metabolic processes. It helps shuttle electrons during glycolysis and the Krebs cycle so you can get those electrons into the electron transport chain.

Why it matters:

  • Activates sirtuins and PARPs (DNA repair + longevity genes)

  • Supports mitochondrial biogenesis (more, better mitochondria)

  • Essential for healthy metabolism, especially with age

When to use it:
If you’re over 35, chronically stressed, or metabolically sluggish, NAD⁺ is your best friend. It doesn’t directly create energy—but it ensures your body can make energy more efficiently over time.

BHB: Clean Energy Fuel, Anytime, Anywhere

What it does:
BHB is a ketone body—the fuel your liver creates when carbs are low or when you’re fasting. Unlike glucose, BHB skips glycolysis and heads straight into the TCA cycle via acetyl-CoA. It’s ultra-efficient and creates more ATP per molecule than glucose—with way less inflammation.

Why it matters:

  • Powers the brain, muscles, and mitochondria when glucose is low

  • Improves mitochondrial function and gene expression

  • Acts as an HDAC inhibitor, which boosts long-term metabolic health

When to use it:
Anytime you want clean energy—fast. Whether you’re fasting, keto, or just want a performance boost without carbs, BHB delivers. And yes, I take goBHB daily because it’s the most bioavailable, clinical-grade ketone on the market. And we make it.

What I Recommend

Here’s the strategy used by top-tier biohackers and athletes:

  • NAD⁺ keeps your metabolic foundation solid

  • BHB gives you clean, efficient fuel for mind and body

  • Methylene Blue optimizes mitochondrial output when things are sluggish or under stress

This trio covers everything: fuel, function, and flow.

Personally, I take goBHB daily—whether I’m fasted, training, or just grinding at work. It sharpens my brain, fuels my body, and keeps my recovery on point. You don’t need to live keto to benefit—you just need better cellular fuel. And Let’s Go! BHB and Rev7 are the easiest ways to get it done.

The Bottom Line

Energy isn’t about caffeine or carbs—it’s about mitochondrial output. And if you’re serious about performance, longevity, and brain power, it’s time to upgrade your stack.

 

BHB. NAD⁺. Methylene Blue.
Different tools. One goal: More ATP. More life.

Ketones While You Sleep? How BHB May Rewire the Aging Brain

Ketones While You Sleep? How BHB May Rewire the Aging Brain

By Marc Lobliner, IFBB Pro 

We all want to train hard, recover faster, and stay sharp as we age. But what if I told you there’s a supplement that not only supports recovery and performance… it might actually enhance your brain while you sleep?

You’ve probably heard about BHB (beta-hydroxybutyrate) and its role in fat loss, clean energy, and mental clarity. But a recent study (PMC10581428, 2023) just dropped a bombshell: BHB could boost deep sleep and overnight memory consolidation—especially in older adults with early cognitive decline.

Yeah. This is huge.

The Study: Ketones, Sleep, and Mild Cognitive Impairment

This randomized crossover trial focused on 17 older adults with mild cognitive impairment (MCI)—the stage between normal aging and early Alzheimer’s. Researchers gave participants either:

  • A ketone ester drink (delivering ~12g of BHB), or

  • A placebo

They then tracked brain activity during sleep using EEG and tested memory the next morning.

Key Findings:

  • Increased slow-wave sleep (SWS) – Participants had significantly more deep sleep after taking BHB

  • Enhanced overnight memory consolidation – Subjects performed better on memory tests after sleeping with ketones in their system

  • No disruption to REM or total sleep time – BHB enhanced quality, not just quantity

Let that sink in. A single dose of BHB before bed improved the depth of sleep and the brain’s ability to lock in new memories.

Why This Matters

Slow-wave sleep is where the magic happens. That’s when your brain repairs itself. Your muscles recover. Your hormones reset. Your memories consolidate. And as we age, SWS declines hard—which is tied to poor cognition, insulin resistance, and even depression.

What this study shows is that raising BHB can help reverse that trend—even without changing your diet or hitting ketosis.

That means:

  • Sharper thinking

  • Better memory

  • Faster recovery

  • And yes, more efficient fat burning and mitochondrial activity

And it all starts while you’re doing nothing—just sleeping.

Real-Life Application: What Do You Do with This?

You could:

  1. Fast for 16 hours (hard)

  2. Eat strict keto (miserable)

  3. Or use goBHB — the same ketone body used in this research — in supplement form

I use goBHB every single day. It’s clean, it’s fast-acting, and it works.

My Go-To: Let’s Go! BHB & Rev7

If I’m training, working late, or pushing high-performance output, I take Rev7 for energy and clarity. But for evening use or recovery, Let’s Go! BHB is next level. It’s BHB with electrolytes and no stims — perfect for pre-bed use.

Stack idea:

  • Morning – Rev7

  • Evening – Let’s Go! BHB
    And enjoy the best sleep of your life while your brain rewires and your body recovers.

The Bottom Line

You already know BHB helps you train better and think clearer. But this new study proves it can also help you sleep deeper and build a better brain while you rest.

This isn’t just about better performance—it’s about protecting your brain, maximizing recovery, and aging like a damn savage.

Whether you’re an athlete, entrepreneur, or just someone who wants to stay sharp for decades to come, BHB might be your new bedtime secret weapon.

Train hard. Sleep smart. Stay ready.

Study Reference:
Papadopoulos, A., et al. (2023). A pilot study of acute nutritional ketosis and overnight sleep and memory in mild cognitive impairment. Cardiovascular Research. PMC10581428

β-Hydroxybutyrate Enhances Mitochondrial Health in Muscle Cells: New Study Shows Cellular and Metabolic Benefits of Ketosis

Study Goal

Researchers wanted to see how β-hydroxybutyrate (β-HB)—a ketone body produced during ketosis—affects the energy powerhouses (mitochondria) in muscle cells.

🧪 What They Did

They tested β-HB in:

  • Mouse muscle cells in a lab
  • Rats fed a ketogenic diet

🧠 What They Found (In Simple Terms)

  1. Better Mitochondrial Function
    Muscle cells treated with β-HB had:
    • More efficient energy production (better oxygen use)
    • Lower harmful byproducts like hydrogen peroxide (H₂O₂), which causes oxidative stress
  2. Increased Cell Survival
    Cells exposed to β-HB were healthier and more viable, showing better growth.
  3. Less Mitochondrial Fragmentation
    β-HB encouraged mitochondria to stay connected (fusion) instead of breaking apart (fission), which is good for cell health.
  4. Reduced Harmful Fat Molecules (Ceramides)
    These ceramides can hurt mitochondria and insulin sensitivity.
    β-HB lowered ceramide levels, possibly explaining the better mitochondrial structure and function.
  5. Ketogenic Diet in Rats Had Similar Effects
    Rats fed a ketogenic diet had:
    • Lower body weight (without losing muscle)
    • Better mitochondrial respiration
    • Less oxidative stress in muscle cells
    • A trend toward less mitochondrial fragmentation

📌 Bottom Line

β-Hydroxybutyrate helps make muscle cells healthier by:

  • Boosting mitochondrial efficiency
  • Reducing oxidative stress
  • Preventing cellular damage
  • Supporting overall muscle cell survival

These benefits may help explain why ketogenic diets can maintain or even improve muscle function, despite having low carbohydrate intake.

🐁 The Mice (C2C12 Myotubes – Muscle Cells in Lab Culture)

The mice were not given a ketogenic diet.

Instead, their muscle cells (C2C12 myotubes) were:

  • Cultured in a lab dish
  • And directly treated with β-hydroxybutyrate (β-HB) at a concentration of 5 mM for 24 to 48 hours

This means:

  • The β-HB was added directly to the cell medium, not through diet.
  • The goal was to isolate the direct effects of β-HB on the mitochondria and cell viability without dietary variables.

Burn More Without Doing More? How Ketones Fire Up Your Fat Cells

Burn More Without Doing More? How Ketones Fire Up Your Fat Cells

By: Marc Lobliner, IFBB Pro

We’ve heard it all before: “Calories in vs. calories out.” But what if your body could crank up the calories out… without you even trying?

Let’s talk about ketones—and no, this isn’t another keto cult pitch. I’m talking about what science is showing us ketones can actually do to your fat cells at a cellular level. And the data? It’s wild.

A study published in the International Journal of Molecular Sciences (PMID: 32872407) dove deep into how the ketone body β-Hydroxybutyrate (βHB) affects the mitochondria—the little engines inside your fat cells. We’re talking about real mitochondrial bioenergetics across human, rodent, and cell models.

What the Science Says

This wasn’t just another observational study. Researchers directly treated skeletal muscle cells with β-Hydroxybutyrate and found:

1. Mitochondrial Respiration Went Through the Roof
Fat cells burned more oxygen:

  • 91% boost in lab-grown adipocytes

  • 113% boost in rodent subcutaneous fat

  • 128% boost in human subcutaneous fat tissue

2. ATP Production Stayed the Same
Despite the increased activity, ATP levels didn’t go up. That means fat cells were using energy inefficiently, burning off fuel as heat instead of storing it—a process called mitochondrial uncoupling.

3. Fat Cells Became Metabolically Active
The study showed increased expression of genes involved in mitochondrial growth and thermogenesis:

  • PRDM16

  • PGC1α

  • UCP1

These are the same genes seen in brown fat—the kind that burns calories to keep you warm. That’s right: your white fat starts acting more like brown fat.

Real-Life Application: How This Changes the Game

If you’ve dieted before, you know the struggle: plateaus, slow metabolism, fatigue. But this study shows that βHB can help keep your mitochondria active, your fat cells inefficient, and your metabolism firing.

This could mean more fat loss, less metabolic slowdown, and better results from the same amount of work. It changes the way we think about fat loss—not just cutting calories, but improving the quality of your energy metabolism.

How to Get the Benefits: Enter goBHB®

You can elevate βHB in two ways:

  1. Fasting or keto dieting

  2. Supplementing with exogenous ketones like goBHB®

GoBHB® is a patented form of βHB that raises your ketone levels fast—no fasting or extreme carb cutting required. It provides a clean, effective source of ketones your body can use immediately.

My Go-To: Rev7 & Let’s Go! BHB

If you want a real-world, daily solution, grab Rev7. It’s a caffeine-free energy drink that features goBHB®. You get clean energy, metabolic support, and better recovery in one convenient dose.

I also recommend Let’s Go! BHB—another high-quality goBHB® formula in a satchet that makes daily ketone use easy and effective, especially for those seeking sustained metabolic benefits without diet extremes.

Whether it’s morning cardio, a heavy training session, or a busy workday, Rev7 and Let’s Go! BHB give you the edge.

The Bottom Line

This study proves it: ketones don’t just fuel your body—they can actually change how your fat cells behave. Burn more, store less, and keep your engine running hot.

With goBHB® and tools like Rev7 and Let’s Go! BHB, you’re not just reacting to your diet—you’re taking control of your metabolism.

Train smart. Eat with purpose. Burn more without doing more.

Reference: Poff, A. M., Koutnik, A. P., Egan, K. M., Sahebjam, S., D’Agostino, D. P. (2020). Ketones Elicit Distinct Alterations in Adipose Mitochondrial Bioenergetics. International Journal of Molecular Sciences, 21(17), 6254. https://pubmed.ncbi.nlm.nih.gov/32872407/