Real Ketones has developed various proprietary exogenous ketone supplement formulas based on its patented Quad Ketone backbone technology for the purposes of accelerating weight loss, fat loss, enhancing lean to fat ratios, improving body composition and bolstering key metabolic markers for improving one’s health. Real Ketones continues to invest significant funds into advancing the knowledge of the benefits of the daily ingestion of exogenous ketones and discovering the most efficacious formulas for its products.

The ketogenic diet is a high-fat, very low-carbohydrate, moderate-protein diet that will induce a state of ketosis, but because of its restrictive nature, it may be difficult to adhere to, especially in adolescents. Supplementing with exogenous beta-hydroxybutyrate salts may induce a state of temporary ketosis without any undesirable side effects, thereby promoting the benefits of ketosis and minimizing adherence requirements to a ketogenic diet. To date, beta-hydroxybutyrate supplementation in healthy adolescents has not been explored. Therefore, the purpose of this study was to examine the safety of exogenous beta-hydroxybutyrate salt supplementation in a healthy adolescent population. In the present study, 22 healthy male and female adolescents consumed 3.75 g of beta-hydroxybutyrate salts or maltodextrin placebo twice daily for 90 days. Comprehensive blood safety analysis, bone densitometry, happiness and emotional intelligence surveys, and blood pressure were assessed at Pre, Day 45, and Day 90. There were no significant differences detected in subjects supplementing with beta-hydroxybutyrate salts, indicating that exogenous beta-hydroxybutyrate salts had no detrimental impact on fasting blood safety metrics, bone density, happiness, emotional intelligence, or blood pressure. We conclude that supplementing with exogenous beta-hydroxybutyrate salts is safe and well-tolerated by healthy adolescents.

The ketogenic diet is a high-fat, very low-carbohydrate, moderate-protein diet that will induce a state of ketosis. Ketosis is a metabolic state characterized by elevated ketone body production in response to the absence of carbohydrates. Some drawbacks of the ketogenic diet are that it can be difficult to adhere to due to its restrictive nature, and it can also cause some undesirable side effects like gastrointestinal distress and increases in apoB-lipoproteins. In order to maximize the benefit of ketosis and to minimize side effects, supplementing with exogenous beta-hydroxybutyrate may induce a state of temporary ketosis without undesirable side effects. In the present study, 22 healthy male and female adults consumed 12.75 grams of beta-hydroxybutyrate salts or maltodextrin placebo twice daily for 90 days. Comprehensive blood safety analysis, body composition, bone densitometry, psychological and immune surveys, and blood pressure were administered at baseline, 30, 60, and 90 days. There were no significant differences in any measures collected, indicating that exogenous beta-hydroxybutyrate had no detrimental impact on fasting blood values such as electrolyte levels, glucose, hemoglobin A1c, complete blood count, body composition, bone density, psychological well-being, immune status, or blood pressure. We conclude that supplementing with exogenous beta-hydroxybutyrate is safe and well-tolerated by healthy adults.

This study tested the hypothesis that 14-days of Ketone supplementation, Keto5 XOGenius, would improve well-validated indices of peripheral micro and macrovascular function in otherwise young healthy adults.

NNB Labs has recently released two groundbreaking studies on BHB, shedding new light on how to determine the true efficacy of BHB supplements and ketone precursors (substances that are not BHB but can convert into BHB). Traditionally, the effectiveness of BHB supplements and precursors (BHB sources) have been measured by their peak levels they reach in the blood. However, this method is flawed as it only captures a fleeting moment, neglecting the overall impact of BHB sources efficacy. These studies challenge the traditional focus on peak BHB levels and emphasize the importance of considering the total quantity of ketones over time and the net ATP yield of each BHB source—the two key metrics that reveal the real value of different BHB sources.

The human body naturally produces endogenous ketones during ketosis (1) and the same has been marketed as a dietary supplement that can be taken in conjunction with a low carb diet. Ketones first came into popularity with the existence of the ketogenic diet (2). Following a ketogenic diet causes the body to use all of its readily available glucose. As a response to this dearth in glucose reserves, the body burns stored fats/ketones (3). There are purportedly myriad benefits associated with this process. Using the body’s storage of fat cells is beneficial for healthy weight loss (4). Additionally, the high proportion of fats that are required for this diet can be utilized to promote lean muscle gain (5). Any fat that isn’t transformed into muscle could become a convenient fuel source. Ketones have also been found to have implications associated with increased mental acuity. A human study determined that those who adhered to this diet displayed improved alertness and cognitive function compared to their non-keto counterparts (6). A non-human study tested the efficiency with which ketones relieve anxiety by monitoring several Sprague Dawley rats adhering to a ketogenic diet and concluded that ketones display serious benefits when it comes to maintaining brain health and relieving anxiety (7).