NNB Labs has recently released two groundbreaking studies on BHB, shedding new light on how to determine the true efficacy of BHB supplements and ketone precursors (substances that are not BHB but can convert into BHB). Traditionally, the effectiveness of BHB supplements and precursors (BHB sources) have been measured by their peak levels they reach in the blood.
However, this method is flawed as it only captures a fleeting moment, neglecting the overall impact of BHB sources efficacy. These studies challenge the traditional focus on peak BHB levels and emphasize the importance of considering the total quantity of ketones over time and the net ATP yield of each BHB source—the two key metrics that reveal the real value of different BHB sources.
The two new NNB studies dive deep into comparing the main sources of BHB in the market, in particular goBHB acid/powders (powders being acid + electrolytes), 1,3-butanediol (a ketone precursor), BHB mono esters (one BHB bonded to 1,3-butanediol), and BHB diesters (two BHBs bonded to 1,3-butanediol).
BEYOND THE PEAK: MEASURING BLOOD KETONES (BHB) WITH AREA UNDER THE CURVE (AUC)
Traditional blood ketone meters focus on peak BHB levels to determine effectiveness. This approach is limited because it only captures a fleeting glimpse of the BHB source’s impact, neglecting the total quantity and duration of BHB in the blood. A more accurate measure is the Area Under the Curve (AUC), which considers the total BHB presence over time, providing a clearer picture of the source’s efficacy.
Study Highlights
In the study “Beyond the Peak: Comparing the Duration and Quantity of Ketones from Three D-BHB Sources,” NNB Labs demonstrated that the total quantity of ketones generated over a two-hour period was relatively equivalent among different D-BHB sources, despite differences in peak levels.
THE TRUE STORY OF BHB SOURCES: NET ATP PRODUCTION
The real value of BHB lies in its ability to yield ATP, the primary energy currency of the body. To accurately assess a BHB source’s efficacy, one must examine its net ATP yield—the amount of ATP generated after accounting for the energy cost of converting the BHB source into bioavailable BHB.
Key Findings
The NNB Labs study “Impact of Different BHB Substrates and Precursors on Liver ATP” revealed significant differences in net ATP yield among various BHB sources. Both goBHB D-BHB and L-BHB enantiomers provided a substantial and continuous ATP boost to the liver. In contrast, 1,3-butanediol and all esters were found to consume excessive amounts of ATP during their conversion process. Specifically, 1,3-butanediol required over seven times the ATP to convert to BHB compared to BHB acid itself.
Furthermore, numerous studies indicate that 1,3-butanediol not only lacks efficacy, but also poses potential risks to liver and kidney health due to its alcohol nature. BHB mono esters contain 41% 1,3-butanediol, and BHB diesters contain 21% 1,3-butanediol.
For example, Karen Clarke from Oxford and Delta G Ketones writes in marketing materials, “…ketone products that contain straight 1,3 butanediol, the alcoholic ketogenic precursor, should never be consumed in an attempt to raise blood ketones for performance, as they will carry the same deleterious effects one would see from ethanol consumption.”
Refer to our detailed paper on 1,3-butanediol for more information.
BEYOND EFFICACY: ADDITIONAL ADVANTAGES OF goBHB
- Taste and Flavoring: goBHB, in both its liquid acid and electrolyte acid powder forms, offers a significantly better flavor profile compared to 1,3-butanediol and esters, which are known for their unpleasant taste. This makes goBHB a much more consumer-friendly option.
- Electrolyte Benefits: goBHB can exist in an electrolyte acid powder form, and upon ingestion releases BHB acid and valuable electrolytes that aid in hydration and electrolyte balance. This is crucial for athletes and individuals with specific workout and lifestyle regimens who need a combination of energy and hydration.
- Formulation Flexibility: goBHB liquid acids and electrolyte acid powders enable the creation of liquid or powdered supplements, offering versatile formulation options. In contrast, 1,3-butanediol and esters are primarily available in liquid form, limiting their use and convenience.
- Alcohol Concerns: 1,3-Butanediol, being an alcohol, poses potential health risks. Its metabolism can increase the burden on the liver and kidneys, raising concerns about long-term use.
- Cost-Effectiveness: goBHB is less expensive per kilogram compared to other BHB sources.
MEASURING L-BHB: THE NEW UNTAPPED POTENTIAL OF BHB TECHNOLOGY
Current ketone measurement devices only measure D-BHB, overlooking the significant presence and potential of L-BHB. This leads to an incomplete understanding of the true power of ketone sources. In one study, L-BHB was finally measured and showed a much higher peak and duration than D-BHB. goBHB is the only brand that can provide both D-BHB and L-BHB in any desired ratio and in both liquid acid and electrolyte acid powder forms.
The Hidden Power of L-BHB
Recent research has revealed that L-BHB fully metabolizes in the body and can play a crucial role in energy production, metabolic regulation, and cellular signaling. While D-BHB is widely studied and appears to be the body’s primary energy source, L-BHB’s unique metabolic pathways and impact might be even more profound. Emerging evidence suggests that L-BHB significantly contributes to the body’s energy dynamics, metabolic signaling, and overall metabolic functionality.
For example, we are working with hospitals on rare diseases using goBHB. One of those diseases, MADD (Multiple Acyl-CoA Dehydrogenase Deficiency), a rare genetic disorder that affects the body’s ability to break down certain fats and proteins for energy.
It was originally believed that D-BHB could be administered to these patients as a fuel source, it was soon discovered that in order for BHB to be effective in supplying energy, it required both L-BHB and D-BHB.
goBHB: THE GOLD STANDARD OF CELLULAR ENERGY
Studies clearly show that D-BHB and L-BHB acid are superior sources of cellular energy. They deliver a direct and sustained ATP boost, aligning with our evolutionary need for stable, efficient fuel during periods of food scarcity.
Fueling Your Success: The Smart Choice for Ketone Supplements
When choosing ketone supplements, focus on the science-backed evidence pointing to ATP production rather than flashy claims about peak BHB levels. It is evident that goBHB is the gold standard. Understanding the true metabolic costs and benefits of different BHB sources empowers you to make informed choices about ingredients that will optimize cellular energy and deliver the most power in a supplement. Based on the positive results from the NNB studies Ketone Labs is moving forward to perform additional human studies on the impact of goBHB on metabolic ATP production.
Unveiling the Truth: Net ATP Production
Science-backed evidence highlights net ATP production as the true measure of a ketone supplement’s efficacy. ATP, the body’s primary energy currency, fuels cellular processes and drives performance. Research has unequivocally demonstrated that BHB acid reigns supreme in net ATP production, outperforming all other BHB sources, especially 1,3-butanediol.
EMPOWERING YOUR PRODUCTS WITH goBHB
By aligning your brand with the scientifically proven superiority of goBHB and leveraging our 81 patents to protect your brand’s use of goBHB, you provide your customers with the most efficient and sustainable energy source. Unlike other BHB sources that deplete cellular energy and pose potential health risks, goBHB delivers the best, clean, powerful boost to cellular function without compromising safety, all at the lowest cost per kilogram.
Are You Ready to Help Fuel Your Success?
NNB Labs’ studies unequivocally demonstrate the superior net ATP production and sustained energy benefits of goBHB compared to other BHB sources, particularly 1,3-butanediol. We at Ketone Labs invite you to choose goBHB, the gold standard of cellular energy for your brand.