Revolutionizing Evening Workouts: A Pre-Workout That Supports Sleep?

At Ketone Labs, we’re solving a common dilemma for evening athletes: how to fuel intense workouts without compromising sleep. In episode 15 of Formulator’s Corner, we introduce two innovative stim-free pre-workout concepts powered by our signature ingredient, goBHB®.

These formulas are designed specifically for 6PM training sessions, offering clean energy without stimulants — and with the unique benefit of promoting better sleep and recovery. No more choosing between performance and rest. This is a bold new direction in performance nutrition — and we’re just getting started.

Dual Fuel: The Future of Sports Nutrition Combines Carbs and Ketones for Peak Performance

A new frontier in sports nutrition is emerging with the concept of “dual fuel” supplementation — combining carbohydrates with exogenous ketones to enhance athletic performance. Traditionally, athletes have relied on carbohydrates to replenish glycogen stores during intense activity. However, new research shows that pairing carbs with ketone bodies, such as beta-hydroxybutyrate (BHB), may extend endurance, reduce glycogen depletion, and provide a more stable energy supply by allowing the body to burn both glucose and ketones simultaneously.

Beyond performance enhancement, the dual fuel approach offers promising physiological benefits. These include reduced lactate production, improved cognitive clarity, and better post-exercise recovery. With supplements like goBHB making this strategy more accessible, athletes and fitness enthusiasts may soon adopt this metabolic synergy as a standard tool for optimizing both energy output and recovery in high-intensity and endurance sports.
(Source: PricePlow Blog)

goBHB is direct Energy

The energy drink category has become absolutely loaded these past couple of years, thanks to established names expanding further, closely related brands expanding into the space, and newcomers trying their hand at the industry. The beverage we have in the spotlight here is certainly not one we saw coming, primarily due to the company behind it being so distant with REV7, a diverse, functional energy drink from the pillow manufacturer MyPillow.

goBHB: The Future of Stimulant-Free Pre-Workouts for Evening Athletes

Evening workouts often pose a challenge: the need for energy and focus without the sleep disturbances caused by traditional stimulant-based pre-workouts. While many stimulant-free options exist, they frequently lack effective energy-boosting components. goBHB, a form of beta-hydroxybutyrate, offers a solution by providing direct cellular energy through ATP production, enhancing both performance and sleep quality.

PricePlow proposes two hypothetical goBHB-powered pre-workout formulations tailored for evening trainers. The first is a realistic, cost-effective blend featuring goBHB, L-citrulline, beta-alanine, creatine monohydrate, and cognitive enhancers like L-tyrosine and citicoline. The second is a full-power version that pushes the boundaries of stimulant-free performance. These concepts aim to inspire brands to develop effective, stimulant-free pre-workouts that support both energy and recovery for those who train later in the day.

Source: blog.priceplow.com/formulators-corner/gobhb-stim-free-preworkouts

β-Hydroxybutyrate Enhances Mitochondrial Health in Muscle Cells: New Study Shows Cellular and Metabolic Benefits of Ketosis

Study Goal

Researchers wanted to see how β-hydroxybutyrate (β-HB)—a ketone body produced during ketosis—affects the energy powerhouses (mitochondria) in muscle cells.

🧪 What They Did

They tested β-HB in:

  • Mouse muscle cells in a lab
  • Rats fed a ketogenic diet

🧠 What They Found (In Simple Terms)

  1. Better Mitochondrial Function
    Muscle cells treated with β-HB had:
    • More efficient energy production (better oxygen use)
    • Lower harmful byproducts like hydrogen peroxide (H₂O₂), which causes oxidative stress
  2. Increased Cell Survival
    Cells exposed to β-HB were healthier and more viable, showing better growth.
  3. Less Mitochondrial Fragmentation
    β-HB encouraged mitochondria to stay connected (fusion) instead of breaking apart (fission), which is good for cell health.
  4. Reduced Harmful Fat Molecules (Ceramides)
    These ceramides can hurt mitochondria and insulin sensitivity.
    β-HB lowered ceramide levels, possibly explaining the better mitochondrial structure and function.
  5. Ketogenic Diet in Rats Had Similar Effects
    Rats fed a ketogenic diet had:
    • Lower body weight (without losing muscle)
    • Better mitochondrial respiration
    • Less oxidative stress in muscle cells
    • A trend toward less mitochondrial fragmentation

📌 Bottom Line

β-Hydroxybutyrate helps make muscle cells healthier by:

  • Boosting mitochondrial efficiency
  • Reducing oxidative stress
  • Preventing cellular damage
  • Supporting overall muscle cell survival

These benefits may help explain why ketogenic diets can maintain or even improve muscle function, despite having low carbohydrate intake.

🐁 The Mice (C2C12 Myotubes – Muscle Cells in Lab Culture)

The mice were not given a ketogenic diet.

Instead, their muscle cells (C2C12 myotubes) were:

  • Cultured in a lab dish
  • And directly treated with β-hydroxybutyrate (β-HB) at a concentration of 5 mM for 24 to 48 hours

This means:

  • The β-HB was added directly to the cell medium, not through diet.
  • The goal was to isolate the direct effects of β-HB on the mitochondria and cell viability without dietary variables.

goBHB Powers BYU to Historic Dual National Championships

Brigham Young University made history at the 2024 NCAA Cross Country Championships by winning both the men’s and women’s titles—an achievement fueled in part by goBHB ketone supplementation. As athletes pushed the limits of endurance, focus, and recovery, goBHB emerged as a key factor behind their peak performance, signaling a new chapter in sports nutrition and competitive training.

Want To QUICKLY Burn Fat Without Losing Muscle? You MUST Watch This! 

What if everything you’ve heard about the keto diet is only half the story?

Dr. Benjamin Bikman reveals the real science behind ketosis and insulin sensitivity and why going keto can transform your body in ways most people don’t understand. From preserving muscle to boosting brain function and gut health, this clip cuts through the hype and delivers the truth about how keto really works—and when it might not.

Bedding brand MyPillow takes a swing at energy drinks with its goBHB and Cognizin powered REV7

The energy drink category has become absolutely loaded these past couple of years, thanks to established names expanding further, closely related brands expanding into the space, and newcomers trying their hand at the industry. The beverage we have in the spotlight here is certainly not one we saw coming, primarily due to the company behind it being so distant with REV7, a diverse, functional energy drink from the pillow manufacturer MyPillow.

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