The World’s Most Powerful Science Backed Ingredient.

BHB has attracted significant attention due to its potential health benefits beyond its role in energy metabolism. Researchers have been exploring the physiological mechanisms underlying the positive effects of BHB on wellness, metabolic health, and longevity.

According to the Global Burden of Disease Study conducted in 2017, it was estimated that around 95% of the global population had at least one health problem or illness, with the remaining 5% considered completely healthy. This study encompassed a wide range of diseases, including both communicable and noncommunicable diseases, injuries, and other health conditions.

Deaths caused by chronic illnesses and related diseases are on the increase worldwide. The percentage of deaths from natural causes versus deaths from disease related causes varies depending on the country and the age group. In the United States, for example, about 80% of deaths in people over the age of 65 are from disease related causes, while about 20% are from natural causes.

Natural causes include things like old age, accidents, and injuries. Disease related causes include things like cancer, heart disease and stroke.

The percentage of deaths from natural causes is decreasing over time as people live longer and healthier lives. The percentage of deaths from disease related causes is increasing over time as people are living longer and are more likely to develop chronic diseases.

Here are some of the leading causes of death in the United States:

• Heart disease: 25.4%
• Cancer: 23.2%
• Chronic lower respiratory diseases: 5.4%
• Accidents (unintentional injuries): 4.6%
• Stroke (cerebrovascular diseases): 4.1%
• Alzheimer’s disease: 2.5%
• Diabetes: 2.4%
• Influenza and pneumonia: 2.2%
• Nephritis, nephrotic syndrome, and nephrosis: 1.9%
• Suicide: 1.4%

As to aging and longevity, life expectancy in the USA has dropped over the past five years. In 2017, life expectancy at birth was 78.6 years. By 2022, it had dropped to 76.1 years. This is a decline of 2.5 years. Coupled with this, the Numbeo Quality of Life Index has dropped over the past five years. In 2017, the average score for all countries was 61.1. By 2022, the average score had dropped to 59.5. This is a decline of 2.8%.

By focusing on obesity in the context of metabolic health, wellness and aging, we can see that obesity leads to major risk factors for many chronic diseases including heart disease, stroke, type 2 diabetes and some types of cancer. A study published in the journal JAMA found that obesity can shorten a person’s life expectancy by an average of 3 to 10 years. The study looked at data from over 100,000 people and found that those who were obese were more likely to die from heart disease, stroke, type 2 diabetes, and some types of cancer.

BHB’S ROLE IN IMPROVING METABOLIC HEALTH

Metabolic health refers to the overall state of an individual’s metabolic functioning, particularly in relation to the processing, utilization, and regulation of energy and nutrients within the body. It involves the proper functioning of metabolic pathways, hormones, enzymes, and organs involved in metabolism such as the liver, pancreas, adipose tissue, and muscles.

Metabolic health is characterized by the body’s ability to efficiently convert food into energy, maintain stable blood glucose levels, regulate lipid metabolism, and effectively utilize and store nutrients. It is associated with factors such as insulin sensitivity, glucose control, lipid profiles, blood pressure, and body composition.

A person with good metabolic health typically exhibits balanced energy metabolism, with efficient utilization of glucose and fatty acids for energy production. They have stable blood glucose levels, low levels of circulating insulin, and a healthy lipid profile, including optimal levels of triglycerides, cholesterol, and lipoproteins. Additionally, individuals with good metabolic health tend to have a healthy body weight, favorable body composition (appropriate ratio of lean mass to fat mass), and normal blood pressure.

On the other hand, poor metabolic health is often characterized by conditions such as insulin resistance, impaired glucose tolerance, dyslipidemia (abnormal lipid profile), obesity, and elevated blood pressure. These conditions increase the risk of developing metabolic syndrome, type 2 diabetes, cardiovascular diseases, and other metabolic disorders.

Overall, metabolic health reflects the body’s ability to carry out metabolic processes effectively and harmoniously, promoting optimal energy utilization, nutrient metabolism, and overall well-being.

Several studies have indicated that good metabolic health is relatively rare in many populations, particularly in developed countries where sedentary lifestyles, unhealthy diets, and obesity rates are higher. For example, a study published in the journal Metabolic Syndrome and Related Disorders in 2014 found that only 12.2% of American adults had optimal metabolic health based on criteria such as blood pressure, glucose control, lipid profiles, and body composition.

goBHB supplementation is a safe and effective way to improve metabolic health. It has been proven to:

• Increase energy levels: BHB can provide a sustained source of natural energy, which can help people to feel more alert and energized throughout the day.
• Weight loss: BHB can help to promote weight loss by increasing the body’s ability to burn fat for energy and delivering appetite suppression.
• Reduce inflammation: BHB has anti-inflammatory properties, which can reduce ROS, improve autophagy and help to improve overall health and well-being.
• Improve brain function: BHB, which passes through the blood brain barrier, can help to improve brain function by providing a source of natural energy for the brain. This can help to improve cognitive function and memory.
• Reduce risk of chronic diseases: BHB has been shown to reduce the risk of chronic diseases such as heart disease, stroke, and type 2 diabetes.

Here are some studies that support the benefits of BHB for metabolic health:

• A study published in the journal “Advanced Nutrition” found that BHB supplementation improved insulin sensitivity and reduced blood sugar levels amongst healthy participants.
• A study published in the Journal of Nutritional Science and Vitaminology showed that a daily intake of BHB decreased the average waist circumference by 9cm amongst healthy adult participants over a 9 week period and this was achieved without dietary restriction or exercise intervention.
• Several studies have investigated the potential neuroprotective effects of BHB in adolescent and adult humans for brain injury. For example, a study published in the journal Frontiers in Neuroscience shows that BHB improved cognitive repair and behavioral outcomes in adolescent males with traumatic brain injury . Another study published in the journal Frontiers of Nutrition shows how BHB supplementation can prevent further damage post-concussion, improve cognitive and motor performance amongst patients with neurogenerative diseases.
• A study in the journal eBioMedicine demonstrates how the ketogenic diet had a favorable effect on reducing Alzheimer’s disease markers amongst subjects with mild cognitive impairment.

BHB’S ROLE IN IMPROVING WELLNESS

Wellness can be defined as a state of overall well-being encompassing various dimensions of health, including physical, mental, emotional, social, and spiritual well-being. It goes beyond the absence of illness and incorporates aspects such as optimal physical fitness, mental clarity, emotional balance, positive social relationships, and a sense of purpose and fulfillment.

Wellness involves actively pursuing a healthy and balanced lifestyle, making conscious choices that promote health, and striving for a harmonious integration of mind, body, and spirit. It is a dynamic process that requires continuous effort and selfcare to achieve and maintain an optimal state of well-being. Wellness is about optimizing health, energy and vitality rather than managing disease.

Wellness is important because it’s a state of existence that can help you live a longer, healthier and happier life. When you are well, you have more energy, you are better able to cope with stress, and you are more likely to make healthy choices. Wellness can also help you to improve your relationships, your work performance, and most of all your overall quality of life. If you are not healthy it detracts from almost all aspects of your life.

In addition to supplementation with exogenous ketones, there are things that can be done to improve your wellness. Some of the most important things from a health perspective include:

• Eating a healthy diet: This means eating plenty of fruits, vegetables, and whole grains. It also means limiting your intake of processed foods, sugary drinks, and unhealthy fats.

– A study published in the journal Nutritional Diabetes in 2017 found that overweight adults with type 2 diabetes on a ketogenic diet lowered their HbA1c, lost significantly more weight and reduced their medication compared with those on a moderate carbohydrate diet over a 12 month period.

– Another study published in the International Journal of Environmental Research and Public Health showed that a state of ketosis suppressed lipogenesis and increased weight loss amongst obese human participants.

– A study published in the journal Nutrients in 2022 discussed how the Ketogenic Diet plays a role in modifying many metabolic pathways with favorable health effects, including to help reduce Cardiovascular Disease.

• Getting regular exercise: Aim for at least 30 minutes of moderate intensity exercise most days of the week.

– A study published in the Journal of the American Medical Association found that people who exercised regularly were less likely to die from all causes than those who did not exercise. Another study, published in the British Journal of Sports Medicine, found that exercise can help to improve cognitive function in older adults.

• Getting enough sleep: Most adults need around 7-8 hours of sleep per night.

– A study published in the journal “Sleep” found that people who got 7-8 hours of sleep per night had a lower risk of heart disease, stroke, and diabetes. The study also found that people who got enough sleep had a lower risk of obesity and other chronic health conditions.

• Managing stress: Find healthy ways to manage stress, like as exercise, relaxation techniques, or spend time with loved ones.

– A study published in the journal “The Lancet” found that stress and anxiety are responsible for 10% of the global burden of disease.

goBHB can help get the body into a ketogenic state. Ketosis is a metabolic state in which the body utilizes ketones for energy. BHB has been shown to have several benefits for health and wellness, including:

• Weight loss: BHB can help to promote weight loss by increasing the body’s metabolic rate and helping to suppress appetite.
• Improved blood sugar control: BHB can help to improve blood sugar control in people with diabetes by reducing insulin resistance.
• Reduced Stress and Anxiety: BHB has been shown to increase brain GABA levels. GABA is a neurotransmitter that plays a role in calming the brain and reducing anxiety. BHB has been shown to increase GABA levels in the brain, which may help to reduce anxiety.
• Reduced inflammation: BHB has anti-inflammatory properties that can help to reduce inflammation throughout the body.
• Improved brain function: BHB can help to improve brain function by providing a source of energy for the brain and by protecting the brain from damage.
• Increased energy levels: BHB can help to increase energy levels by providing a source of natural energy for the body. BHB has 225% more energy than carbs.
• Improved athletic performance: BHB can help to improve athletic performance by providing a source of energy for the body and by helping to reduce fatigue.
• Improved Sleep: BHB can help get you into a deeper sleep as well as reducing sleep disturbances. One study found that people who took BHB supplements for 8 weeks had significantly more time spent in deep sleep than those who took a placebo. Another study found that BHB supplements improved sleep quality in children.
• Improved Mood: BHB may help to improve mood by increasing levels of the neurotransmitter’s serotonin and dopamine. One study published in the journal Frontiers of Psychiatry investigated the effects of a bhb supplement on anxiety in adult individuals. The study found that the ketone drink raised BHB levels, and significantly alleviated anxiety levels.
• Another study published in Frontiers in Psychiatry investigated the effects of a ketogenic diet, which increases BHB levels, as a mood stabilizer for patients with anxiety disorders. The study found that the ketogenic diet significantly improved perceived mood and reduced anxiety amongst human patients.

BHB is a better metabolic fuel. Its more powerful, cleaner, and does not require an active transport to move it into mitochondria. BHB impacts wellness and if taken regularly can improve many different bio-markers of health.

BHB’S ROLE IN AGING AND LONGEVITY

Aging is a metabolic condition associated with the loss of mitochondria and mitochondrial function. As cells age, mitochondria can become damaged by oxidative stress and other factors associated with aging. This reduction in the number and efficiency of cell mitochondria leads to a diminished capacity for producing ATP.

ATP is the basic currency of energy used by the muscles, brain, organs, and other biological functions. As ATP production slows, the body reacts by shutting down biological functions that are less essential—such as cell proliferation, including the formation of new skin cells, heart cells, brain cells—to ensure that there is enough ATP to carry out the metabolic functions essential for maintaining life (such as those pertaining to the brain, heart, and other vital organs). The body acts on these choices by using epigenetic switching to silence the genes associated with less vital bodily functions. The goal is to keep all the switches turned on to all the vital bodily functions.

Another key factor related to aging is oxidative stress. It is considered one of the hallmarks to aging and thought to actively contribute to the development of chronic diseases, including neurodegeneration. Normal physiological reactions in the body, as well as exogenous sources, produce reactive oxygen species (ROS). Over time, accumulation of ROS-related damage leads to age-associated tissue and organ function losses. The accumulation of ROS-related damage results from increased production of ROS and/or decreased antioxidant defenses against the ROS. Excessive ROS causes aging by damaging organs, tissue, and DNA directly through oxidizing bases, causing strand breaks. Indirectly ROS can impact DNA damage through Ionizing radiation, UVA radiation, and chemical agents. It has been suggested that the age-associated decline in blood levels of certain antioxidants may be a risk factor for neurodegeneration in the elderly.

Whether you are talking metabolic health, wellness or aging, preventing cellular senescence, a state of irreversible cell cycle arrest in which a cell loses its ability to divide and proliferate, is key to vital living. Senescence can be triggered by various factors, including DNA damage, telomere shortening, oxidative stress, oncogene activation, and certain cellular stressors. All though senescent cells remain metabolically active they undergo significant changes in their gene expression, morphology, and function. As humans age, metabolic health and wellness become the challenge and reducing the number of senescent cells becomes the objective. As senescent cells increase they can impair tissue function and contribute to chronic inflammation. Senescent cells secrete various pro-inflammatory factors, growth factors, and matrix-degrading enzymes, collectively known as the senescence-associated secretory phenotype (SASP). The SASP can promote tissue dysfunction, chronic inflammation, and the development of age-related pathologies.

The control and removal of senescent cells is critical for overall metabolic health and wellness. Senescent cells can release harmful factors that can damage surrounding cells and tissues. They can also interfere with the normal function of organs and tissues. BHB helps to control and remove senescent cells in a number of ways.

First, BHB can induce the death of senescent cells through a process called apoptosis. Apoptosis is a natural process of cell death that is important for maintaining the health of the body. BHB can induce apoptosis in senescent cells by activating a protein called p53. p53 is a tumor suppressor protein that plays a role in regulating cell growth and death. In a study published in the journal Nature Medicine, researchers found that BHB was able to induce apoptosis in senescent cells. The researchers also found that BHB was able to suppress the production of inflammatory factors by senescent cells. Dr David Sinclair, author of ‘Lifespan’ has shown how a low sugar diet maintains cell health and prevents cell senescence; this contributes to fewer biomarkers of disease (and aging) and longer lifespans.

Second, BHB can suppress the production of inflammatory factors by senescent cells. Inflammatory factors can damage surrounding cells and tissues and contribute to the development of diseases. BHB can suppress the production of inflammatory factors by senescent cells by activating a protein called AMPK. AMPK is a metabolic sensor that plays a role in regulating inflammation.

Third, BHB can increase the production of antioxidants by the body. Antioxidants can help to protect cells from damage by free radicals. Free radicals are unstable molecules that can damage cells and tissues. BHB can increase the production of antioxidants by the body by activating a protein called Nrf2. Nrf2 is a transcription factor that regulates the expression of genes involved in antioxidant defense. In a study published in the journal Aging, researchers found that BHB was able to increase the production of antioxidants by the body. The researchers also found that BHB was able to protect cells from damage by free radicals.

Fourth, BHB can help elevate the effects of fasting, exercise and calorie restriction in causing autophagy.

Longevity is the length of time a person or organism lives. Although longevity and aging are associated with each other, aging is a process and longevity is an outcome. It is somewhat intuitive to think that the prevention of aging automatically increases longevity, but that is not necessarily true. Someone can slowly age and then suddenly succumb to a sudden chronic disease, or lose their cognitive functionality as in the case in dementia and Alzheimer’s disease.

Longevity is such a pervasive goal in everyone’s life, in our public health policies and in popular social media that billions of dollars are spent trying to achieve this elusive goal. There are perhaps as many reasons for wanting to live longer as there are individuals.

However, coupled to living longer is the quality of life issue. In many different surveys most people only want to live longer lives if it will translate to quality healthy living. So even as longevity is a very valued public health objective, at the individual level longer lives are a goal only if people can remain healthy.

STRATEGIES TO SLOW THE AGING PROCESS AND INCREASE QUALITY LONGEVITY

Looking at aging and longevity in a holistic view, it is arguable that healthy aging provides the means for enjoyable longevity. This means a long disease ridden life has been judged to have less value than a shorter healthy and active life.

Fundamentally, aging contains both a metabolic and genetic component. Aging is recognized as a complex process that involves both metabolic and genetic factors, including changes in cellular processes, DNA damage, and the accumulation of cellular waste can lead to a decline in physiological function and an increased risk of age-related diseases. While aging is presently thought to be a natural and unavoidable process, certain dietary lifestyle choices along with proper supplementation strategies can be utilized to not only (1) slow down or even reverse the aging process, but (2) promote overall health that leads to quality longevity.

Two major factors contributing to aging is the decline in mitochondrial function and mitochondrial proliferation.

The metabolism of BHB is associated with several beneficial effects including anticonvulsant effects, enhanced metabolism by the brain, neuroprotection, muscle sparing properties, and improved cognitive and physical performance. Science-based improvements in efficiency of cellular metabolism, managed through BHB supplementation, can have beneficial impacts on physical and cognitive health, psychological health, and a long-term impact on health with respect to the common avoidable diseases such as obesity, cardiovascular disease, neurodegenerative diseases, diabetes, and cancer. Many of these are associated with aging and loss of a quality of life status.

BHB has been found to be a vital metabolic and signaling mediator with different biological roles coming from the different enantiomers of beta hydroxybutyrate. BHB is known to have a repertoire of therapeutic benefits and provide options for mitigating diseases of the nervous system, with prospective roles in cancer, as well as having intriguing protective roles in heart and liver, opening therapeutic options in obesity-related and cardiovascular disease. The signaling capability of ketones is continued to be explored in their ability to turn on and off different epigenetic and metabolic switches through ketone metabolism removing much of the classical dogma of ketones simply being an energy metabolite with limited function and application.

Recent studies now point to additional roles for BHB in cellular metabolism, metabolic homeostasis, and a wide range of signaling of physiological, epigenetic and pathological states. Apart from serving as the body’s preferred energy fuel for extrahepatic tissues like the brain, heart, or skeletal muscles, ketone bodies appear to play pivotal roles as signaling mediators, drivers of protein post-translational modification (PTM), and significant modulators of inflammation and oxidative stress. Moreover, research is now starting to point to BHB as having the ability to mediate epigenetics opening a whole new world of modern thinking about the role of ketone bodies and their metabolism in human function and health.

BHB is processed differently in the mitochondria than glucose. BHB gives mitochondria their unique characteristics in the production of ATP, reduces reaction oxygen species and reduces oxidative stress on a cellular level.

BHB has numerous positive metabolic impacts such as:

• Causing weight loss and allowing for better weight maintenance, suppressing appetite, sparing muscle loss, increasing fat loss, improving body composition
• Elevating and maintaining blood ketone levels, maintaining blood ketone levels, reducing blood glucose levels, maintaining blood glucose levels
• Improving focus, and brain energy, increasing cognitive function
• Reducing the effects of traumatic brain injury
• Controlling glucose and insulin in type 2 diabetes
• Reducing neurological disorders, epilepsy, depression
• Impacting cancer tumor growth
• Controlling inflammatory conditions
• Impacting anti-aging, fibroblast reactivation, anti-glycation
• Increasing performance and strength

BHB will be one of the key ingredients to mastering aging and longevity in our lifetimes.

BHB’S ROLE IN IMPROVING METABOLIC HEALTH

BHB is and will be one of the true keys to achieving metabolic health, improved wellness, the slowing of aging, and improving longevity. Simply put BHB is the master energy molecule capable of:

• Weight loss: BHB can help to promote weight loss by increasing the body’s metabolic rate and helping to suppress appetite.
• Improved blood sugar control: BHB can help to improve blood sugar control in people with diabetes by reducing insulin resistance.
• Reduced inflammation: BHB has anti-inflammatory properties that can help to reduce inflammation throughout the body.
• Improved brain function: BHB can help to improve brain function by providing a source of energy for the brain and by protecting the brain from damage.
• Increased energy levels: BHB can help to increase energy levels by providing a natural source of energy for the body.
• Improved athletic performance: BHB can help to improve athletic performance by providing a source of energy for the body and by helping to reduce fatigue.
• Improved sleep: BHB may help to improve sleep by reducing sleep disturbances such as tossing and turning, and by increasing total sleep time.
• Reduced stress: BHB reduces stress levels, which can improve sleep quality.
• Improved mood: BHB may help to improve mood, which can also improve sleep quality.
• Anti-aging: BHB may help to slow down the aging process by protecting cells from damage and by promoting cell regeneration.
• Increased longevity: BHB may help to increase longevity by reducing the risk of chronic diseases and by promoting overall health and well-being.

BHB has the potential to improve a variety of health conditions that promote wellness. BHB is a safe and natural compound that can be used by people of all ages and health conditions.

REFERENCES

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