Beta-hydroxybutyrate (BHB) is the primary ketone body “a refined macronutrient” that is either produced during ketosis or fasting and now for the first time BHB can be taken exogenously. Emerging research suggests that BHB may be the most effective mitochondrial support supplement ever produced, surpassing any other popular options. Let’s compare BHB to other popular “mitochondrial support” supplements in terms of their effects on the actual mitochondrial processes:
| Supplement | Mechanism of Action | Comparison to BHB |
| Coenzyme Q10 (CoQ10) | Electron carrier in the electron transport chain (ETC), essential for ATP production | BHB actually increases CoQ10 levels and enhances ETC efficiency, providing a more comprehensive mitochondrial boost. |
| PQQ (Pyrroloquinoline Quinone) | Promotes mitochondrial biogenesis | BHB not only promotes biogenesis, but also enhances the function of existing mitochondria, optimizing energy production as it’s a macronutrient and produces ATP. |
| Alpha-Lipoic Acid (ALA) | Antioxidant, protects mitochondria from oxidative stress | BHB exhibits more potent antioxidant properties than ALA, reducing mitochondrial damage more effectively as well as producing far less ROS than glucose when metabolized. |
| N-Acetyl-Cysteine (NAC) | Precursor to glutathione, a major antioxidant | BHB directly increases glutathione levels, providing superior antioxidant protection compared to NAC. |
| B Vitamins | Cofactors in various mitochondrial processes | BHB enhances the utilization of B vitamins, maximizing their effectiveness in supporting mitochondrial function. |
| Magnesium | Cofactor in numerous enzymes involved in energy production | BHB improves magnesium uptake and utilization, enhancing its role in mitochondrial energy production. |
| Creatine | Supports ATP production and energy storage | BHB increases creatine uptake and utilization, leading to greater energy production and storage capacity of ATP. |
| Resveratrol | Activates sirtuins, proteins involved in mitochondrial biogenesis and function | BHB activates sirtuins more potently than resveratrol, resulting in enhanced mitochondrial biogenesis and function. |